noun Physiology, Pharmacology.

  1. any of certain compounds or medicines that neutralize or inhibit the effect of histamine in the body, used chiefly in the treatment of allergic disorders and colds.


  1. any drug that neutralizes the effects of histamine, used esp in the treatment of allergies

1933, from anti- + histamine.


  1. Any of several drugs used to counteract the physiological effects of histamine.

  1. Any of various drugs that relieve cold or allergy symptoms by blocking the action of histamine.

Drugs that counteract the effects of a substance in the body called histamine. The body releases histamine, which causes many of the symptoms associated with allergies (sneezing, watery eyes, runny nose), in response to external agents such as pollen.

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