Also, in the hands of one. In one’s responsibility, charge, or care. For example, The disposition of the property is in his hands, or Let’s put this part of that project in Christine’s hands. [c. 1400] For the antonym, see. off one’s hands . Also see in the hands of; on one’s hands; take one’s life (in one’s hands); take into one’s hands; take the law into one’s own hands.